Formulation And Evaluation of Controlled Drug Delivery Systems for Enhanced Therapeutic Efficacy

Abstract

The use of controlled drug delivery systems is now seen as a successful way to improve the effectiveness of drugs by making them more bioavailable and giving a steady release. In this research, different polymer-based drug delivery systems were formulated and checked to determine the best concentration for particle size, drug encapsulation and the way the drug was delivered. The formulations were analyzed for their particle size, checked using DSC and studied by in vitro drug release tests. A greater amount of polymer was found to result in bigger particles, better drug entrapment and a better-regulated release of the drug, most likely due to the combined effects of diffusion and polymer erosion. Tests showed that the formulations did not change physically or chemically when stored in different conditions. The results of cytotoxicity assays showed that the materials are safe and can be used in clinical work. According to these findings such delivery systems are successful at keeping drug levels in the body steady, leading to fewer injections for patients and better compliance with treatment. Researchers should focus on testing these polymers in living organisms and apply the approaches to other combinations of drugs and polymers.